Shilo is a genetically ill teenager locked in her house for life as her doctor father Nathan is keeping a dark secret about her mother.
Rotti Largo who shares the same secret, is the greedy and arrogant owner of GeneCo, a biotech company that offers organ transplants.
He thinks he is god but hates his children who are totally freaks.
He is caring only for business and when his customers miss their payments he sends the Repo Man, a vicious killer who eliminate them and take back their implants.
Soon the secrets will be exposed and lives of Shilo, Nathan and Rotti will be involved into the wildly anticipated spectacular event: The Genetic Opera with the worst sequences.